For instruments, tube is definitely the way to go. I love my old '68 Sunn 200S (with mostly Dynaco innards) for my bass guitar, and it's the loudest amp rated for 50 watts (two 6550 or KT88) that I've ever heard, easily keeping up with Marshall stacks the rare times I play big venues. It drives two Aguilar bins, after my ridiculously heavy EV SRO 15s from the early '70s needed a recone, and OEM kits were no longer available, except substandard ones from China. We had a great run! The other 90% of the time, it's my workhorse Harke Kickback 12, which is just an awesome piece of kit. It improved greatly (and lost weight) when I blew the original driver at a gig one night, thankfully right at the end, and replaced it with an Eminence Basslite neo magnet speaker. Larry Hartke is a local Long Island boy who's not only a great guy, but really stands behind his stuff too.
On the audio side, I've always lusted after a Dynaco ST-70 tube amp, but have been quite happy with my Nakamichi Sr-4a from the late '80s. The STASIS circuitry in the amp section is particularly good, designed by living legend Nelson Pass. Not sure if my geezer ears (that have been playing and attending loud shows since the '70s) could tell the difference between my Nakamichi and the Dynaco anymore.